The present report summarizes the results of the application of the proposed methodologies for drought identification and characterization, risk analysis and risk management for water supply systems to the Italian case study, namely the Simeto river basin in Sicily. In particular, after a general description of the case study (section 2), the results of the drought identification study, carried out by means of several indices and methods such as SPI, Palmer indices and run method, are presented (section 3). The application of a methodology proposed for the assessment of the return periods of drought events identified on the historical annual precipitation series is also presented. In section 4, after a general classification, the drought mitigation measures historically adopted for the Simeto river basin to reduce drought impacts in urban and agricultural sectors are described. Then, in section 5, the methodology for risk analysis presented in chapter 6 is applied to the Salso-Simeto water supply system, which is a part of the larger system of the Simeto river. In particular, a Montecarlo simulation of the system, making use of synthetically generated hydrological series and a water supply system simulation model, is carried out in order to assess both unconditional (long term) and conditional (short term) drought risk. Finally impact assessment on rainfed agriculture is presented.