Different water regimes, saline water/treated wastewater alternation to optimize nitrogen application, reduce groundwater nitrate pollution risk and determine the supplemental irrigation feasibility to stabilize the bread wheat yield were tested. The high value of reusing treated wastewater with appropriate practices is demonstrated: treated wastewater gave similar to better growth and yield and the same quality of crop irrigated with reclaimed wastewater in comparison to the control; drip irrigation and plastic mulch eliminated the coliform contamination risk of the harvested products; the nitrogen mass balance for the crops receiving treated wastewater indicates high risk of nitrate groundwater. Flowering is the most critical growth stage. The units receiving the highest water amounts at flowering produce the largest yield. When applying denitrification process and tertiary treated wastewater (using reed bed), NO3and P levels were low and didn't meet plant nutrition requirements with 200 mm dose, and induced soil nitrate reduction.