A twelve-week experiment investigated the effects of replacing fish meal (FM) with dehulled hexane extracted soybean meal (SBM) and the addition of enzymes on the growth and feed utilization of 50 g gilthead sea bream, Sparus aurata, fed to satiation. Three levels of SBM, 220, 320 and 440 g/kg, and FM, 320, 260 and 230 g/kg respectively were used in these pressed diets, and two diets FM two enzyme cocktails were added to the latter to give a total of 7 treatments. Growth and feed utilization decreased as the level of SBM increased. The addition of 1 g/kg of a low pH active protease together with 1 g/kg of an a-galactosidase (a-gal) and of 1 g/kg of a high pH active protease together with 1 g/kg of the a-gal to the diet containing 320 g/kg SBM brought improvements in the nutritional parameters studied. The best performance was given by fish fed the former of these two diets, and both performed better than diet containing higher FM. The results indicate the potential for improving feed performance by the addition of enzymes to the food.