Citrus tristeza virus (CTV) is present in most of the Mediterranean countries, usually inducing the quick decline of all citrus spp. when grafted onto the sour orange rootstock, which is highly susceptible. The presence in Northern Portugal and Spain of T. citricidus represents a serious threat to the Mediterranean citrus industry since the virus inoculum is widely distributed in the whole region and the susceptible sour orange is the predominant rootstock. Considering the socio-economic and environmental importance of citrus in the Mediterranean region, preventive measures should soon be applied (strict quarantine measures, virus and vector monitoring, elimination of infected plants, certification of propagating material), while the elimination of the severe virus strains and, eventually, the pre-immunization of nursery plants should be considered in case of failure. This situation prompted CIHEAM/Mediterranean Agronomic Institute of Bari to urgently promote a harmonized common action for the control of the virus and BrCA in the whole region in the framework of the activities of the Mediterranean Research Network on Certification of Citrus (MNCC). The regional proposal developed and endorsed by MNCC country representatives will be presented to their governments in order to submit it to different donors as a priority issue for the Region.