Pomegranate is the fruit of the Punica Granatum tree, which grows in Mediterranean countries. Its therapeutic properties have been used to treat different conditions (cardiovascular, neurological, diabetes and cancer) for hundreds of years. Numerous in vitro and in vivo studies have recently shown the antioxidant, anti-inflammatory and anti-tumoral properties of pomegranate. Antiproliferative, proapoptotic, antiangiogenic and inhibition of tumor invasion have been proven in several experimental models of urological tumors such as in prostate cancer. Pomegranate juice has been shown to delay PSA duplication time in patients with biochemical cancer recurrence after initial treatment. Many phase II studies are currently in progress to demonstrate the effectiveness of pomegranate juice in several diseases and in prostate cancer.