This study aimed to compare grain yield, marketing price and net return per unit area of durum wheat vs. bread wheat in the South-East Anatolia.16 bread wheat + 9 durum wheat advanced lines were tested employing randomized complete block design with 3 replications in 2010-11 and 2011-12 cropping seasons in 2 locations (Ş.urfa and Adıyaman) in each year. Mean separations for grain yields of combined analysis of variance (ANOVA) indicated that bread wheat in average over yielded durum wheat with 7.14%. Rank stability analysis further indicated that bread wheat entries fell into high stable area more than durum wheat. Marketing prices of entries was estimated in Ş.Urfa commodity market. Durum wheat entries in average received higher marketing price offers than bread wheat with 4.97%. A visual characteristic of 1000 kernel weight affected marketing prices for both durum and bread wheat significantly (r= 0.699**). Average net return of bread wheat in average was higher than that of durum wheat with 2.6%. Additional premium (as much as 2 times of Std. deviation of marketing prices) given to highest income generating durum wheat entry did not change the profitability rank. It was concluded that higher yielding bread wheat entries generated higher net returns. Unless purchasers give adequate premium to durum wheat, farmer preference for durum wheat cannot be achieved under supplementary irrigation in SE. Anatolia.