This study has been conducted with the objectives of determining the physiological responses and performance of pure Awassi and East-Friesian x Awassi crossbred ewes (F1, F2 and B1Aw equals to backcross to Awassi) under Çukurova subtropical climatic conditions. Some of their physiological parameters such as rectal temperature, respiration and pulse rate have been taken at 7.00-8.00 a.m., at midday 11.00-12.00 and at 14.00-15.00 during the course of the experiment. In addition to this, their production performance such as litter size, lactation milk yield and lactation length have been determined. According to the results obtained, it is evident that the Awassi breed is superior to the crossbred genotypes in adaptability to the region's conditions. On the other hand, it can be said that B1Aw genotype has shown higher adaptability and in relation to this, they have shown higher performance than the other ewe groups.