Agricultural drainage water reuse is well developed in Egypt, particularly in the Nile Delta region. However, the drainage reuse practices has been threatened by the deteriorating drain water quality due to municipal and industrial wastewater pollution. The government is implementing different programmes for improving the irrigation system and changing water allocation among the regions and water use sectors, which will alter the patterns of drainage availability and the drainage water management perspective. Such programmes are the irrigation improvement programme and the government strategy to reduce size of the cultivated area with the high water requirement crops. This paper investigates the potential impacts of these programmes on drainage water availability and on its suitability for reuse. It highlights several strategic drainage reuse issues such as the minimum drainage outflow requirements to maintain the ecological life features in the northern lakes and to help controlling the seawater intrusion, and pollution control.