Septoria tritici blotch is the most important disease of durum wheat in Tunisia. Control of this disease focuses mainly on the use of genetic resistance of the host plant. Continuous screening in Tunisia lead to the identification of lines with partial resistance. Crosses of this genetic material to high yielding and widely adapted germplasm resulted in the selection of high yielding and resistant durum wheat lines. Accumulation of gene effects and detection and use of tolerance are also important components of this breeding activity.