Somatic Cell Score (SCS) was analysed using 36,873 data of this trait in Manchega ewes. Firstly genetic parameter estimation was carried out using multivariate animal models including SCS Lactation mean (SCSL) and other milk traits. Analysis were made within 1st, 2nd and 3rd lactations separately and also with multiple lactations under repeatability and multivariate approaches considering SCSL as the same or different trait throughout lactations. Heritability estimates of SCSL and other milk traits under models without repeatability were higher. Genetic correlations among SCSL in different lactations were moderate to high. Genetic correlation between SCSL and milk yield was low and negative, however, was positive between SCSL and protein content. Pearson and Spearman correlation coefficients of estimated breeding of animals showed modest favourable correlations between the Estimated Breeding Value (EBV) for SCSL and milk yield and positive between SCSL and protein content.