Vjosa Valley (Albania) represents a transnational area of considerable biodiversity values, in terms of habitat, flora and fauna diversity and for the presence of rare, Balkan and endemic species. It is the only place in Albania where Arbutus andrachne grows. It is considered to be a typical zone of floristic links between Albania and its neighbouring countries, Greece in particular. In addition to the scientific values, this zone in the South of Albania is well known for its cognitive and landscape values as well as its great potential for tourism development. The paper reports information on the identification of bio-climatic zones and plant associations and shows some utilisation of biological diversity.