The safety is assessed by the analysis of the genetic construct and on the evaluation of the risk for human, animal and the environment. The substantial equivalence of the products, particularly of grains and seeds has been established according to international rules. A significant reduction in the level of mycotoxin fumonisin has been observed on genetically modified maize kernel engineered for resistance to the European corn borer, linked with a decrease in the contamination by Fusarium moulds through less damaged ears. Additional evidences on both the safety and the nutritional equivalence have also been provided by the results of chronic experiments conducted in vivo on laboratory and farm animals. On the basis of the present knowledge, feeds derived from genetically modified plants authorised in the European Union can be considered as safe constituents to be incorporated in diets of farm animals.