Syngenta is, a leading company in agribusiness with operations world-wide. Syngenta implemented the concept of “integrated crop solution” years ago in order to give concrete answers to the growers, in terms of availability of complete, innovative, and easy to manage solutions in agricultural practises, to meet the market requirements in term of yield and food safety. For field crops such as wheat, the concept is carried out establishing a link between genetics, breeding, crop protection and agronomical know-how during different stages of wheat varieties development, focusing on the synergy of all combined technical inputs. One of the most interesting example is the development of durum wheat varieties with enhanced tolerance to Fusarium head blight, that was screened evaluating the combined synergic response with different fungicide applications on disease level symptoms and mycotoxins content. Other ongoing goals in cereal breeding focus on combining genetics, crop enhancer products, and growth regulators; these different approaches can achieve relevant results in terms of resistance to biotic and abiotic stress acting, for example, on root development and biochemical modification for an improved tolerance to soil and environmental adverse conditions in optimal balance with yield and quality requirements.